Article
Microarray data analysis: a hierarchical T-test to handle heteroscedasticity.
Applied bioinformatics - 1 Jan 2004
de Menezes Renée X, Boer Judith M, van Houwelingen Hans C
Abstract excerpt
The analysis of differential gene expression in microarray experiments requires the development of adequate statistical tools. This article describes a simple statistical method for detecting differential expression between two conditions with a low number of replicates. When comparing two group means using a traditional t-test, gene-specific variance estimates are unstable and can lead to wrong conclusions. We...
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