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Article

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation.

Nucleic acids research - 1 May 2012

McCarthy Davis J, Chen Yunshun, Smyth Gordon K

Abstract excerpt

A flexible statistical framework is developed for the analysis of read counts from RNA-Seq gene expression studies. It provides the ability to analyse complex experiments involving multiple treatment conditions and blocking variables while still taking full account of biological variation. Biological variation between RNA samples is estimated separately from the technical variation associated with sequencing...

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Identifiers

PMID: 22287627
DOI: 10.1093/nar/gks042
PMCID: PMC3378882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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