Article

Recalibrating differential gene expression by genetic dosage variance prioritizes functionally relevant genes

2024-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Differential expression (DE) analysis is a widely used method for identifying genes that are functionally relevant for an observed phenotype or biological response. However, typical DE analysis includes selection of genes based on a threshold of fold change in expression under the implicit assumption that all genes are equally sensitive to dosage changes of their transcripts. This tends to favor...

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Literature Corpus work: 81392c04-66c8-5656-bf76-86445bb7fc14
DOI: 10.1101/2024.04.10.588830

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