Article
Intra- and inter-individual variance of gene expression in clinical studies.
PloS one - 1 Jan 2012
Cheng Wei-Chung, Shu Wun-Yi, Li Chia-Yang, Tsai Min-Lung, Chang Cheng-Wei, Chen Chaang-Ray, Cheng Hung-Tsu, Wang Tzu-Hao, Hsu Ian C
Abstract excerpt
BACKGROUND: Variance in microarray studies has been widely discussed as a critical topic on the identification of differentially expressed genes; however, few studies have addressed the influence of estimating variance. METHODOLOGY/PRINCIPAL FINDINGS: To break intra- and inter-individual variance in clinical studies down to three levels--technical, anatomic, and individual--we designed experiments and algorithms...
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