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Article

Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model.

Kidney international - 1 Dec 2010

Leelahavanichkul Asada, Yan Qin, Hu Xuzhen, Eisner Christoph, Huang Yuning, Chen Richard, Mizel Diane, Zhou Hua, Wright Elizabeth C, Kopp Jeffrey B, Schnermann Jürgen, Yuen Peter S T, Star Robert A

Abstract excerpt

The remnant kidney model in C57BL/6 mice does not develop progressive chronic kidney disease (CKD). In this study we modified the model to mimic features of human CKD and to define accelerants of disease progression using three strains of mice. Following the procedure, there was a progressive increase in albuminuria, progressive loss in renal function, severe glomerulosclerosis and interstitial fibrosis,...

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Identifiers

PMID: 20736988
DOI: 10.1038/ki.2010.287
PMCID: PMC3113489

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Source receipt: pubmed, retrieved 7 Sept 2026.

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