Article
Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2020
Nakagawa Pablo, Nair Anand R, Agbor Larry N, Gomez Javier, Wu Jing, Zhang Shao Yang, Lu Ko-Ting, Morgan Donald A, Rahmouni Kamal, Grobe Justin L, Sigmund Curt D
Abstract excerpt
Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The classical renin isoform (renin-a) encoding preprorenin is mainly confined to the juxtaglomerular cells and released into the circulation upon stimulation. Alternatively, renin-b is predicted to remain intracellular and is...
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