Article
Allele frequencies of +874T --> A single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients.
Aging clinical and experimental research - 1 Aug 2003
Scola Letizia, Licastro Federico, Chiappelli Martina, Franceschi Claudio, Grimaldi Luigi M, Crivello Antonio, Colonna-Romano Giuseppina, Candore Giuseppina, Lio Domenico, Caruso Calogero
Abstract excerpt
BACKGROUND AND AIMS: Inflammation seems to play a role in progressive neurological degenerative diseases such as Alzheimer's disease (AD). Local inflammatory processes can in fact give rise to direct neurotoxicity, interfere with beta-amyloid expression and metabolism, and maintain chronic, intracerebral, acute-phase protein secretion, in turn favoring the formation of beta-amyloid fibrils. Accordingly, recent...
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