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Article

Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians.

Experimental gerontology - 1 Jan 2000

Lio Domenico, Scola Letizia, Crivello Antonio, Bonafè Massimiliano, Franceschi Claudio, Olivieri Fabiola, Colonna-Romano Giuseppina, Candore Giuseppina, Caruso Calogero

Abstract excerpt

Ageing is characterized by a pro-inflammatory status which could contribute to the onset of major age-related diseases such as cardiovascular diseases, neurodegeneration, osteoarthritis and osteoporosis, and diabetes. Thus, it can be hypothesized that genetic variations in pro- or anti-inflammatory cytokines might influence successful ageing and longevity. We have studied the distribution of +874T-->A...

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PMID: 11772518
DOI: 10.1016/s0531-5565(01)00198-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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