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Cytokine gene polymorphisms and Alzheimer's disease in Brazil.

Neuroimmunomodulation - 1 Jan 2013

Moraes Clayton F, Benedet Andrea L, Souza Vinícius C, Lins Túlio C, Camargos Einstein F, Naves Janeth O S, Brito Ciro J, Córdova Cláudio, Pereira Rinaldo W, Nóbrega Otávio T

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms in genes encoding immunological mediators can affect the biological activity of these molecules by regulating transcription, translation, or secretion, modulating the genetic risk of inflammatory damage in Alzheimer's disease (AD). Nonetheless, the Brazilian contingent is highly admixed, and few association trials performed herein with AD patients have considered...

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PMID: 23838435
DOI: 10.1159/000350368

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