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+10 T/C polymorphisms in the gene of transforming growth factor-beta1 are associated with neurodegeneration and its clinical evolution.

Mechanisms of ageing and development - 1 Oct 2007

Arosio Beatrice, Bergamaschini Luigi, Galimberti Lorenza, La Porta Caterina, Zanetti Mariella, Calabresi Carmen, Scarpini E, Annoni Giorgio, Vergani Carlo

Abstract excerpt

Transforming growth factor-beta1 (TGF-beta1) acts as an immunosuppressant by inhibiting the expression of several pro-inflammatory cytokines. Its gene contains single nucleotide polymorphisms (SNPs) at codon +10 (T-->C) and +25 (G-->C) that appear to influence the level of expression of TGF-beta1. We investigated these SNPs in 198 healthy controls (HC), 193 patients with Alzheimer's disease (AD) and 48 patients...

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PMID: 17889927
DOI: 10.1016/j.mad.2007.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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