Article
APOE epsilon-4 allele and cytokine production in Alzheimer's disease.
International journal of geriatric psychiatry - 1 Apr 2010
Olgiati Paolo, Politis Antonis, Malitas Petros, Albani Diego, Dusi Sabrina, Polito Letizia, De Mauro Stefania, Zisaki Aikaterini, Piperi Christina, Stamouli Evangelia, Mailis Antonis, Batelli Sara, Forloni Gianluigi, De Ronchi Diana, Kalofoutis Anastasios, Liappas Ioannis, Serretti Alessandro
Abstract excerpt
OBJECTIVE: The APOE epsilon-4 allele has consistently emerged as a susceptibility factor for Alzheimer's disease (AD). Pro-inflammatory cytokines are detectable at abnormal levels in AD, and are thought to play a pathophysiological role. Animal studies have shown dose-dependent correlations between the number of APOE epsilon-4 alleles and the levels of pro-inflammatory cytokines. The aims of this study were to...
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