Article
IFNG +874T/A polymorphism is not associated with American tegumentary leishmaniasis susceptibility but can influence Leishmania induced IFN-gamma production.
BMC infectious diseases - 24 Apr 2007
Matos Guilherme Inocêncio, Covas Claudia de J Fernandes, Bittar Rita de Cássia, Gomes-Silva Adriano, Marques Fabiana, Maniero Viviane C, Amato Valdir S, Oliveira-Neto Manoel P, Mattos Marise da Silva, Pirmez Claude, Sampaio Elizabeth P, Moraes Milton O, Da-Cruz Alda Maria
Abstract excerpt
BACKGROUND: Interferon-gamma is a key cytokine in the protective responses against intracellular pathogens. A single nucleotide polymorphism (SNP) located in the first intron of the human IFN-gamma gene can putatively influence the secretion of cytokine with an impact on infection outcome as demonstrated for tuberculosis and other complex diseases. Our aim was to investigate the putative association of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.