Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model.

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Article

Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model.

International journal of oncology - 1 Jan 2004

Kikuchi Yasushi, Sudo Akemi, Mitani Hiroaki, Hino Okio

Abstract excerpt

The Eker (Tsc2 mutant) rat model of renal carcinoma is an example of Mendelian dominantly inherited predisposition to a specific cancer. Effects of genetic background on renal carcinogenesis in the Eker rat model (Eker/Eker > Eker/BN strain) indicate the presence in the BN rat genome of a modifier gene(s) that suppresses tumorigenesis. The identification of such a modifier gene(s) might help clarify the diversity...

Topics

Alkylating Agents
Animals
Carcinoma, Renal Cell
Chromosome Mapping
Chromosomes, Mammalian
Crosses, Genetic
Ethylnitrosourea
Female
Genes, Tumor Suppressor
Genotype
Injections, Intraperitoneal
Kidney
Kidney Neoplasms
Lod Score

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microsatellite Repeats

Mutation

Precancerous Conditions

Source

Open in PubMed

Identifiers

PMID: 14654943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.