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Article

TSC2 gene mutant (Eker) rat model of a Mendelian dominantly inherited cancer.

Progress in experimental tumor research - 1 Jan 1999

Hino O, Fukuda T, Satake N, Kobayashi T, Honda S, Orimoto K, Yamashita Y, Kikuchi Y

Abstract excerpt

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Topics

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Share to Carcinoma, Renal Cell
Share to Genes, Dominant
Share to Germ-Line Mutation
Share to Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Rats, Mutant Strains

Share to Tuberous Sclerosis

Share to Tuberous Sclerosis Complex 2 Protein

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 10377754
DOI: 10.1159/000062006

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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TSC2 gene mutant (Eker) rat model of a Mendelian dominantly inherited cancer.PMID 10377754Read ↗

[Cancer genetics of TSC2 gene mutant(Eker) rat model].Semantic proximity Read ↗

A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancerSemantic proximity Read ↗

The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene.Semantic proximity Read ↗

Identification of tuberous sclerosis 2 messenger RNA splice variants that are conserved and differentially expressed in rat and human tissues.Semantic proximity Read ↗

Uterine leiomyoma in the Eker rat: A unique model for important diseases of womenSemantic proximity Read ↗

Use of the spontaneous Tsc2 knockout (Eker) rat model of hereditary renal cell carcinoma for the study of renal carcinogens.Semantic proximity Read ↗

Renal carcinogenesis: genotype, phenotype and dramatype.Semantic proximity Read ↗

Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells.Semantic proximity Read ↗

Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.Semantic proximity Read ↗

Multistep renal carcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model--genotype, phenotype and environment.Semantic proximity Read ↗

Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model.Semantic proximity Read ↗

Establishment of Tsc2‑deficient rat embryonic stem cells.Semantic proximity Read ↗

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