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Article

Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype.

Genes, chromosomes & cancer - 1 Dec 2003

Hino Okio

Abstract excerpt

Cancer is a heritable disorder of somatic cells. Environment and heredity both operate in the origin of human cancer. The Eker (Tsc2 gene mutant) rat model of hereditary renal carcinoma (RC) is an example of Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. To the best of our knowledge, this was the first isolation of a Mendelian dominantly predisposing cancer gene in a...

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PMID: 14566856
DOI: 10.1002/gcc.10265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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