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Article

Estrogen treatment enhances hereditary renal tumor development in Eker rats.

Carcinogenesis - 1 Nov 1998

Wolf D C, Goldsworthy T L, Donner E M, Harden R, Fitzpatrick B, Everitt J I

Abstract excerpt

Hormonal influences are known to affect the development of renal cell carcinoma in man and laboratory animal models. We tested the hypothesis that estrogen treatment or ovariectomy of rats modulates renal tumor development using tuberous sclerosis 2 (Tsc2) heterozygous mutant (Eker) rats in which a germline mutation predisposes the animals to renal cell tumor development. Two-month-old female wild-type and Eker...

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PMID: 9855022
DOI: 10.1093/carcin/19.11.2043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Estrogen treatment enhances hereditary renal tumor development in Eker rats.PMID 9855022Read ↗

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Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2).Semantic proximity Read ↗

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Renal carcinogenesis: genotype, phenotype and dramatype.Semantic proximity Read ↗

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