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Article

Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model.

Current molecular medicine - 1 Dec 2004

Hino Okio

Abstract excerpt

Cancer is a heritable disorder of somatic cells. Environment and heredity both contribute to the origin of human cancer. The Eker (Tsc 2 gene mutant) rat model of hereditary renal carcinoma (RC) is an example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. To the best of our knowledge, this was the first isolation of a Mendelian dominantly predisposing cancer...

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Identifiers

PMID: 15579027
DOI: 10.2174/1566524043359692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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