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Article

The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population.

Tissue antigens - 1 Jan 2004

Laine A P, Hermann R, Knip M, Simell O, Akerblom H K, Ilonen J

Abstract excerpt

In addition to the known human leukocyte antigen (HLA)-associated risk, polymorphisms of insulin gene region show association with type 1 diabetes. We analyzed possible interactions between the HLA class II genotypes and -2221 MspI (insulin) INS gene polymorphism in Finnish population, using a series of 1331 diabetic children and 2222 healthy newborns. C/C genotype was increased among diabetic children compared...

Topics

Child
Diabetes Mellitus, Type 1
Finland
Genetic Predisposition to Disease
Genotype
HLA Antigens
Humans
Insulin
Polymorphism, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 14651526
DOI: 10.1111/j.1399-0039.2004.00153.x

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population.PMID 14651526Read ↗

Effect of polymorphism in the insulin gene region on IDDM susceptibility and insulin secretion. The Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations.Semantic proximity Read ↗

Insulin gene VNTR polymorphisms -2221MspI and -23HphI are associated with type 1 diabetes and latent autoimmune diabetes in adults: a meta-analysis.Semantic proximity Read ↗

5' insulin gene polymorphism confers risk to IDDM independently of HLA class II susceptibility.Semantic proximity Read ↗

Increased risk of type 1 diabetes in Polish children - association with INS-IGF2 5'VNTR and lack of association with HLA haplotype.Semantic proximity Read ↗

Strong association of insulin gene INS-VNTR polymorphisms with type 1 diabetes in the Romanian population.Semantic proximity Read ↗

In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.Semantic proximity Read ↗

Type 1 diabetes is insulin -2221 MspI and CTLA-4 +49 A/G polymorphism dependent.Semantic proximity Read ↗

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes.Semantic proximity Read ↗

Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.Semantic proximity Read ↗

Effect of polymorphism in insulin locus and HLA on type 1 diabetes in four ethnic groups in Israel.Semantic proximity Read ↗

Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population.Semantic proximity Read ↗

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