Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes.

doi:10.1016/j.diabres.2023.110256

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Article

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes.

Diabetes research and clinical practice - 1 Mar 2023

Taka Antti-Mathias, But Anna, Lempainen Johanna, Vatanen Tommi, Härkönen Taina, Ilonen Jorma, Knip Mikael

Abstract excerpt

The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

Topics

Humans
Child
Diabetes Mellitus, Type 1
Finland
Genetic Predisposition to Disease
Genotype
Incidence

Source

Open in PubMed

Identifiers

PMID: 36640866
DOI: 10.1016/j.diabres.2023.110256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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