Article
Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations.
Disease markers - 1 Jan 2007
Laine Antti-Pekka, Holmberg Hanna, Nilsson Anita, Ortqvist Eva, Kiviniemi Minna, Vaarala Outi, Akerblom Hans K, Simell Olli, Knip Mikael, Ludvigsson Johnny, Ivarsson Sten-A, Larsson Karin, Lernmark Ake, Ilonen Jorma
Abstract excerpt
We have developed high-throughput tests for the detection of the insulin gene region SNPs -23HphI and -2221MspI. The potential of these markers to enhance the efficiency of type 1 diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence-specific hybridization and time-resolved fluorometry reading....
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