Article
In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.
Diabetologia - 1 Oct 1995
Metcalfe K A, Hitman G A, Fennessy M J, McCarthy M I, Tuomilehto J, Tuomilehto-Wolf E
Abstract excerpt
An association between insulin-dependent diabetes mellitus (IDDM) and polymorphisms of the insulin gene on chromosome 11p15 (INS) is a consistent finding in Europid populations. While one study suggested that the INS association is restricted to HLA-DR4-positive individuals, studies in other Europid populations have shown the disease-associated INS genotype to confer susceptibility independently of HLA-DR. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.