Article
In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.
Diabetologia - 1 Oct 1995
Metcalfe K A, Hitman G A, Fennessy M J, McCarthy M I, Tuomilehto J, Tuomilehto-Wolf E
Abstract excerpt
An association between insulin-dependent diabetes mellitus (IDDM) and polymorphisms of the insulin gene on chromosome 11p15 (INS) is a consistent finding in Europid populations. While one study suggested that the INS association is restricted to HLA-DR4-positive individuals, studies in other Euro...
Topics
- Adolescent
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Europe
- Finland
- Genetic Predisposition to Disease
- Genotype
- HLA-DR Antigens
- HLA-DR4 Antigen
- Humans
- Incidence