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Article

5' insulin gene polymorphism confers risk to IDDM independently of HLA class II susceptibility.

Diabetes - 1 Jun 1993

van der Auwera B J, Heimberg H, Schrevens A F, van Waeyenberge C, Flament J, Schuit F C

Abstract excerpt

The polymorphic variable number of tandem repeats in the 5' upstream region of the human insulin gene is a well-known non-human leukocyte antigen locus contributing to genetic susceptibility to IDDM. Controversy exists about the question as to whether INS susceptibility haplotypes are or are not...

Topics

Adolescent
Adult
Aged
Diabetes Mellitus, Type 1
Female
Genetic Predisposition to Disease
Genotype
HLA-D Antigens
HLA-DQ Antigens
HLA-DR Antigens
Humans
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Phenotype

Polymorphism, Genetic

Source

Identifiers

PMID: 8495808
DOI: 10.2337/diab.42.6.851

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8495808-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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5' insulin gene polymorphism confers risk to IDDM independently of HLA class II susceptibility.PMID 8495808Read ↗

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