Article
p53 gene inactivation in acute lymphoblastic leukemia of B cell lineage associates with chromosomal breakpoints at 11q23 and 8q24.
Leukemia - 1 Jun 1995
Lanza C, Gaidano G, Cimino G, Lo Coco F, Basso G, Sainati L, Pastore C, Nomdedeu J, Volpe G, Parvis G
Abstract excerpt
The clinical heterogeneity of acute lymphoblastic leukemia (ALL) of B cell lineage reflects the presence of distinct molecular pathways leading to well-defined ALL molecular subtypes. These molecular pathways include the formation of the fusion transcripts BCR/ABL and E2A/PBX1, due to t(9;22) and...
Topics
- Base Sequence
- Bone Marrow
- Burkitt Lymphoma
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 8
- DNA, Neoplasm
- DNA-Binding Proteins
- Exons
- Fusion Proteins, bcr-abl
- Gene Rearrangement
- Genes, myc