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TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis.

Blood - 10 Jul 2014

Stengel Anna, Schnittger Susanne, Weissmann Sandra, Kuznia Sabrina, Kern Wolfgang, Kohlmann Alexander, Haferlach Torsten, Haferlach Claudia

Abstract excerpt

TP53 is the most extensively studied gene in cancer. However, data on frequency and the prognostic impact of TP53 mutations in acute lymphoblastic leukemia (ALL) remain scarce. Thus, we aimed at identifying the mutation frequency of TP53, its association with cytogenetic subgroups, and its impact on survival in a large cohort of 625 patients with ALL. Our data revealed an overall mutation incidence of 15.7%,...

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Source

Identifiers

PMID: 24829203
DOI: 10.1182/blood-2014-02-558833

Genes

MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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