Article
Mutations of the p53 gene in adult T-cell leukemia.
Blood - 15 Jan 1992
Sakashita A, Hattori T, Miller C W, Suzushima H, Asou N, Takatsuki K, Koeffler H P
Abstract excerpt
The p53 tumor suppressor gene was examined by direct sequencing of polymerase chain reaction-amplified DNA from fresh tumor cells of 10 patients with adult T-cell leukemia (ATL). Samples included nine patients with acute or lymphomatous ATL, and one patient in whom samples were examined in both h...
Topics
- Adult
- Aged
- Base Sequence
- CD4 Antigens
- Codon
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Leukemia, T-Cell
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction