Article
Mutations of the p53 gene in adult T-cell leukemia.
Blood - 15 Jan 1992
Sakashita A, Hattori T, Miller C W, Suzushima H, Asou N, Takatsuki K, Koeffler H P
Abstract excerpt
The p53 tumor suppressor gene was examined by direct sequencing of polymerase chain reaction-amplified DNA from fresh tumor cells of 10 patients with adult T-cell leukemia (ATL). Samples included nine patients with acute or lymphomatous ATL, and one patient in whom samples were examined in both his acute and chronic stages of ATL. Four missense mutations and one silent point mutation in the coding region of the...
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