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Article

Perturbation from a distance: mutations that alter LacI function through long-range effects.

Biochemistry - 2 Dec 2003

Swint-Kruse Liskin, Zhan Hongli, Fairbanks Bonnie M, Maheshwari Atul, Matthews Kathleen S

Abstract excerpt

Allosteric modification of ligand binding is central to LacI transcription control. Recently, the conformational change between LacI operator- and inducer-bound states was simulated with targeted molecular dynamics (TMD) [Flynn, T. C., Swint-Kruse, L., Kong, Y., Booth, C., Matthews, K. S., and Ma, J. (2003) Protein Sci., 12, 2523-2541]. Atomic-level analyses of TMD results indicate the structural importance of...

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Share to Isopropyl Thiogalactoside
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14636069
DOI: 10.1021/bi035116x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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