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Article

Engineering allostery.

Trends in genetics : TIG - 1 Dec 2014

Raman Srivatsan, Taylor Noah, Genuth Naomi, Fields Stanley, Church George M

Abstract excerpt

Allosteric proteins have great potential in synthetic biology, but our limited understanding of the molecular underpinnings of allostery has hindered the development of designer molecules, including transcription factors with new DNA-binding or ligand-binding specificities that respond appropriately to inducers. Such allosteric proteins could function as novel switches in complex circuits, metabolite sensors, or...

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Identifiers

PMID: 25306102
DOI: 10.1016/j.tig.2014.09.004
PMCID: PMC4254034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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