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Article

The genotype-phenotype landscape of an allosteric protein.

Molecular systems biology - 1 Mar 2021

Tack Drew S, Tonner Peter D, Pressman Abe, Olson Nathan D, Levy Sasha F, Romantseva Eugenia F, Alperovich Nina, Vasilyeva Olga, Ross David

Abstract excerpt

Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling, and metabolism. Yet a quantitative understanding of allosteric genotype-phenotype relationships remains elusive. Here, we report the large-scale measurement of the genotype-phenotype landscape for an allosteric protein: the lac repressor from Escherichia coli, LacI. Using a method that combines long-read and short-read...

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Identifiers

PMID: 33784029
DOI: 10.15252/msb.202010179
PMCID: PMC8009258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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