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Article

LacI strikes a balance between stability and inducibility.

Nucleic acids research - 19 Mar 2026

Yuan Jinwen, Lüking Malin, Zikrin Spartak, Sen Beer Chakra, Marklund Emil, van der Spoel David, Fange David, Elf Johan

Abstract excerpt

Transcription factors (TFs) efficiently locate their target DNA sequences by combining three-dimensional diffusion and one-dimensional sliding on nonspecific DNA. To balance rapid sliding with strong specific binding, TFs were proposed to switch between search and recognition conformations. For Escherichia coli lac repressor (LacI), the folding of the hinge helices has been implicated in the conformational...

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Identifiers

PMID: 41954984
DOI: 10.1093/nar/gkag296
PMCID: PMC13069688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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