Article
Operator DNA sequence variation enhances high affinity binding by hinge helix mutants of lactose repressor protein.
Biochemistry - 12 Sept 2000
Falcon C M, Matthews K S
Abstract excerpt
The mechanism by which genetic regulatory proteins discern specific target DNA sequences remains a major area of inquiry. To explore in more detail the interplay between DNA and protein sequence, we have examined binding of variant lac operator DNA sequences to a series of mutant lactose repressor proteins (LacI). These proteins were altered in the C-terminus of the hinge region that links the N-terminal DNA...
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