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Article

Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology.

Neuroscience letters - 4 Dec 2003

Iivonen Susan, Helisalmi Seppo, Mannermaa Arto, Alafuzoff Irina, Lehtovirta Maarit, Soininen Hilkka, Hiltunen Mikko

Abstract excerpt

A genetic association of an intronic single nucleotide polymorphism site of heparan sulfate proteoglycan 2 (HSPG2) with Alzheimer's disease (AD) was investigated among Finnish AD patients (n=213) and controls (n=269). No association of the HSPG2 polymorphism alone was observed with AD. However, an association of HSPG2 A allele with AD was detected in apolipoprotein (APOE) epsilon4 allele carriers. The odds ratio...

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Source

Identifiers

PMID: 14625044
DOI: 10.1016/j.neulet.2003.08.041

Genes

HSPG2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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