Article
Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese.
Neurobiology of aging - 1 Jun 2008
Ma Suk Ling, Tang Nelson Leung Sang, Zhang Ya Ping, Ji Lin-dan, Tam Cindy Woon Chi, Lui Victor Wing Cheong, Chiu Helen Fung Kum, Lam Linda Chiu Wa
Abstract excerpt
Cyclooxygenase-2 (COX-2, encoded by the gene prostaglandin-endoperoxide synthase 2, PTGS2) is a key enzyme in the conversion of arachidonic acid to prostaglandins. The prostaglandins produced by COX-2 are involved in inflammation and pain response in different tissues in the body. Enhanced COX-2 expression had been found in regions of brains from patients with Alzheimer's disease (AD). Here, we proceeded to test...
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