Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD.

doi:10.1016/j.neurobiolaging.2010.07.017

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Article

Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD.

Neurobiology of aging - 1 Jan 2012

Lebedeva Elena, Stingl Julia C, Thal Dietmar R, Ghebremedhin Estifanos, Strauss Joachim, Özer Esra, Bertram Lars, von Einem Björn, Tumani Hayrettin, Otto Markus, Riepe Matthias W, Högel Josef, Ludolph Albert C, von Arnim Christine A F

Abstract excerpt

Beta-amyloid 42 (Aβ42) concentrations in cerebrospinal fluid (CSF) are significantly decreased in Alzheimer's disease (AD). The aim of this study was to correlate genetic variability in presenilin 2 (PSEN2) in relation to Aβ42 concentrations and to confirm association of apolipoprotein E (APOE) alleles E4/E4 genotype with lower CSF Aβ42. Haplotype analysis of PSEN2 and APOE genotyping were performed in 175...

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Identifiers

PMID: 20850903
DOI: 10.1016/j.neurobiolaging.2010.07.017

Genes

APOE
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.