Article
Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele.
Acta neuropathologica - 1 Sept 1998
Ghebremedhin E, Schultz C, Botez G, Rüb U, Sassin I, Braak E, Braak H
Abstract excerpt
Argyrophilic grain disease (AGD) is a distinct degenerative disorder of the human brain associated with the formation of abnormally phosphorylated tau protein. AGD-related cytoskeletal changes are known to affect specific subsets of nerve cells and oligodendrocytes. Here we demonstrate a remarkable association between the apolipoprotein E (ApoE) epsilon2 allele and AGD. Individuals afflicted with AGD (n = 48)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.