Article
Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele.
Acta neuropathologica - 1 Sept 1998
Ghebremedhin E, Schultz C, Botez G, Rüb U, Sassin I, Braak E, Braak H
Abstract excerpt
Argyrophilic grain disease (AGD) is a distinct degenerative disorder of the human brain associated with the formation of abnormally phosphorylated tau protein. AGD-related cytoskeletal changes are known to affect specific subsets of nerve cells and oligodendrocytes. Here we demonstrate a remarkab...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E2
- Apolipoproteins E
- Brain
- Brain Chemistry
- DNA
- Dementia
- Diagnosis, Differential
- Female
- Gene Frequency
- Genotype
- Humans
- Liver
- Male
- Middle Aged