Article
Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
International journal of molecular medicine - 1 Aug 2007
Andersson Malin E, Sjölander Annica, Andreasen Niels, Minthon Lennart, Hansson Oskar, Bogdanovic Nenad, Jern Christina, Jood Katarina, Wallin Anders, Blennow Kaj, Zetterberg Henrik
Abstract excerpt
Kinesin is a microtubule-associated motor protein that transports Alzheimer-associated amyloid precursor protein (APP) in neurons. In animal models, impaired kinesin-mediated APP transport seems to enhance formation of the neurotoxic 42 amino acid fragment of beta-amyloid (A beta 42). In man, one study suggests that a polymorphism (rs8702, 56,836G>C) in the kinesin light chain 1 gene (KNS2) may affect the risk of...
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