Article
Alpha2 macroglobulin and the risk of Alzheimer's disease.
Neurology - 25 Jan 2000
Dodel R C, Du Y, Bales K R, Gao F, Eastwood B, Glazier B, Zimmer R, Cordell B, Hake A, Evans R, Gallagher-Thompson D, Thompson L W, Tinklenberg J R, Pfefferbaum A, Sullivan E V, Yesavage J, Alstiel L, Gasser T, Farlow M R, Murphy G M, Paul S M
Abstract excerpt
BACKGROUND: alpha2 Macroglobulin is a panproteinase inhibitor that is found immunohistochemically in neuritic plaques, a requisite neuropathologic feature of AD. Recently, a pentanucleotide deletion near the 5' end of the "bait region" of the alpha2 macroglobulin (A2M) gene was reported to be associated with AD in a large cohort of sibpairs, in which the mutation conferred a similar odds ratio with AD as the...
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