Article
Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL.
Gastroenterology - 1 Dec 2000
de la Concha E G, Fernandez-Arquero M, Lopez-Nava G, Martin E, Allcock R J, Conejero L, Paredes J G, Diaz-Rubio M
Abstract excerpt
BACKGROUND & AIMS: IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because these HLA class II alleles may confer susceptibility to ulcerative colitis, we investigated an...
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