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Article

The role of -850 tumor necrosis factor-alpha and apolipoprotein E genetic polymorphism in patients with Down's syndrome-related dementia.

Neuroscience letters - 27 Nov 2003

Lucarelli Paola, Piciullo Antonella, Verdecchia Magda, Palmarino Mariella, Arpino Carla, Curatolo Paolo

Abstract excerpt

Down's syndrome (DS) is a disease with a complex etiology. It is likely that other factors besides genes located on chromosome 21 may play a role in clinical features of affected patients. Tumor necrosis factor-alpha (TNF-alpha) (6p21.3) and apolipoprotein E (APOE) (19q13.2) are candidate genes as they interact with the brain deposition of Abeta, one of the neuropathological hallmarks in DS. We examined 136 DS...

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Source

Identifiers

PMID: 14615042
DOI: 10.1016/j.neulet.2003.08.021

Genes

APOE
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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