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Apolipoprotein E genotypic frequencies among Down syndrome patients imply early unsuccessful aging for ApoE4 carriers.

Rejuvenation research - 1 Sept 2007

Forte Giusi I, Piccione Maria, Scola Letizia, Crivello Antonino, Galfano Cristina, Corsi Massimiliano M, Chiappelli Martina, Candore Giuseppina, Giuffrè Mario, Verna Roberto, Licastro Federico, Corsello Giovanni, Caruso Calogero, Lio Domenico

Abstract excerpt

Down syndrome (DS) might be considered a model for unsuccessful and early aging, possibly accelerated for those who carry the APOE4 allele associated with common age-related diseases, e.g., Alzheimer's disease and a poor prognosis after acute myocardial infarction, causing lower ApoE4 frequencies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17559337
DOI: 10.1089/rej.2006.0525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17559337-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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