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Article

Beta-amyloid, oxidative stress and down syndrome.

Current Alzheimer research - 1 Dec 2006

Lott Ira T, Head Elizabeth, Doran Eric, Busciglio Jorge

Abstract excerpt

Down syndrome (DS) provides a model for studying important aspects of Alzheimer disease (AD). Chromosome 21 contains several genes that have been implicated in neurodegenerative mechanisms. These include Cu/Zn superoxide dismutase (SOD-1), Ets-2 transcription factors, Down Syndrome Critical Region 1 (DSCR1) stress-inducible factor, and the amyloid precursor protein (APP). The accumulation of Abeta plaques is...

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Source

Identifiers

PMID: 17168651
DOI: 10.2174/156720506779025305

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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