Article
Potential bias in Generalized Estimating Equations linkage methods under incomplete information.
Genetic epidemiology - 1 Jan 2006
Lebrec J, Putter H, van Houwelingen J C
Abstract excerpt
The mean identity-by-descent (IBD) specification used in the Generalized Estimating Equations (GEE) methodology for linkage is only valid, strictly speaking, under the assumption of fully polymorphic markers. In practice, markers often provide only partial IBD information, which can potentially result in inconsistency of the locus location and gene effect estimates obtained by the GEE method. Using both...
Topics
- Alleles
- Bias
- Chromosome Mapping
- Confidence Intervals
- Cytogenetic Analysis
- Genetic Markers
- Humans
- Models, Genetic