Article
Appropriate use of information on family history of disease in recruitment for linkage analysis studies.
Annals of human genetics - 1 May 2006
Wallace C, Clayton D G
Abstract excerpt
When conducting genetic studies for complex traits, large samples are commonly required to detect any of the number of genes with relatively low effect thought to underly such traits. This is because, in contrast to monogenic diseases, complex traits typically result from a number of different genetic pathways (genetic heterogeneity) and any sample is likely to contain a considerable fraction of sporadic cases...
Topics
- Family Health
- Genetic Linkage
- Genetic Variation
- Humans
- Medical History Taking
- Patient Selection
- Sample Size