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Article

Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003

Srivastava Meera, Montagna Cristina, Leighton Ximena, Glasman Mirta, Naga Shanmugam, Eidelman Ofer, Ried Thomas, Pollard Harvey B

Abstract excerpt

Annexin 7 (ANX7) acts as a tumor suppressor gene in prostate cancer, where loss of heterozygosity and reduction of ANX7 protein expression is associated with aggressive metastatic tumors. To investigate the mechanism by which this gene controls tumor development, we have developed an Anx7(+/-) knockout mouse. As hypothesized, the Anx7(+/-) mouse has a cancer-prone phenotype. The emerging tumors express low levels...

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Identifiers

PMID: 14608035
DOI: 10.1073/pnas.2235927100
PMCID: PMC283584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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