Article
In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals.
Cell cycle (Georgetown, Tex.) - 1 Aug 2013
Badeaux Mark A, Jeter Collene R, Gong Shuai, Liu Bigang, Suraneni Mahipal V, Rundhaug Joyce, Fischer Susan M, Yang Tao, Kusewitt Donna, Tang Dean G
Abstract excerpt
The current study was undertaken to investigate potential oncogenic functions of NanogP8, a tumor-specific retrogene homolog of Nanog (expressed in pluripotent cells), in transgenic animal models. To this end, human primary prostate tumor-derived NanogP8 was targeted to the cytokeratin 14 (K14) cellular compartment, and two lines of K14-NanogP8 mice were derived. The line 1 animals, expressing high levels of...
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