Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.

Nature - 9 Dec 2004

Mao Jian-Hua, Perez-Losada Jesus, Wu Di, Delrosario Reyno, Tsunematsu Ryosuke, Nakayama Keiichi I, Brown Ken, Bryson Sheila, Balmain Allan

Abstract excerpt

The FBXW7/hCDC4 gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mouse Fbxw7 gene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Radiation-induced lymphomas from p53+/- mice, but not those from p53-/- mice, show frequent loss of heterozygosity and a 10% mutation rate of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to F-Box Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to F-Box-WD Repeat-Containing Protein 7

Share to Genes, Tumor Suppressor

Share to Loss of Heterozygosity

Share to RNA, Small Interfering

Share to Survival Rate

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 15592418
DOI: 10.1038/nature03155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.PMID 15592418Read ↗

Clinical significance of FBXW7 loss of function in human cancersSemantic proximity Read ↗

FBXW7/hCDC4 is a general tumor suppressor in human cancer.Semantic proximity Read ↗

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.Semantic proximity Read ↗

FBXW7: a critical tumor suppressor of human cancers.Semantic proximity Read ↗

Recent insight into the role of FBXW7 as a tumor suppressor.Semantic proximity Read ↗

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas.Semantic proximity Read ↗

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.Semantic proximity Read ↗

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.Semantic proximity Read ↗

Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation.Semantic proximity Read ↗

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Semantic proximity Read ↗

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.Semantic proximity Read ↗

Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.