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Article

Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia.

Blood - 1 Mar 2004

Ferrando Adolfo A, Herblot Sabine, Palomero Teresa, Hansen Mark, Hoang Trang, Fox Edward A, Look A Thomas

Abstract excerpt

Aberrant expression of transcription factor oncogenes such as HOX11, HOX11L2, TAL1/SCL, LYL1, LMO1, and LMO2 can be detected in lymphoblasts from up to 80% of patients with acute T-cell lymphoblastic leukemia (T-ALL). Transcriptional activation of these oncogenes in leukemic cells typically results from chromosomal rearrangements that place them next to highly active cis-acting transcriptional regulatory...

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Share to Basic Helix-Loop-Helix Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia-Lymphoma, Adult T-Cell

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Source

Identifiers

PMID: 14604958
DOI: 10.1182/blood-2003-07-2577

Genes

TAL1
LMO2
LMO1
LYL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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