Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

doi:10.1182/blood-2016-09-742148

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Article

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

Blood - 15 Jun 2017

Rahman Sunniyat, Magnussen Michael, León Theresa E, Farah Nadine, Li Zhaodong, Abraham Brian J, Alapi Krisztina Z, Mitchell Rachel J, Naughton Tom, Fielding Adele K, Pizzey Arnold, Bustraan Sophia, Allen Christopher, Popa Teodora, Pike-Overzet Karin, Garcia-Perez Laura, Gale Rosemary E, Linch David C, Staal Frank J T, Young Richard A, Look A Thomas, Mansour Marc R

Abstract excerpt

Somatic mutations within noncoding genomic regions that aberrantly activate oncogenes have remained poorly characterized. Here we describe recurrent activating intronic mutations of LMO2, a prominent oncogene in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in PF-382 and DU.528 T-ALL cell lines in addition to 3.7% of pediatric (6 of 160) and 5.5% of adult (9 of 163) T-ALL...

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Identifiers

PMID: 28270453
DOI: 10.1182/blood-2016-09-742148
PMCID: PMC5472898

Genes

LMO2
ETS1
MYB
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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