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Article

The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A

29 Oct 2021

Abstract excerpt

Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and lymphatic TCL1 family of oncogenes, i.e., the paradigmatic TCL1A, but also TML1 or MTCP1, is causally implicated in T- and B-lymphocyte transformation. TCL1A also...

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PMID: 34771618
DOI: 10.3390/cancers13215455

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