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Article

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.

Oncogene - 10 Mar 2011

Draheim K M, Hermance N, Yang Y, Arous E, Calvo J, Kelliher M A

Abstract excerpt

The most common translocation in childhood T-cell acute lymphoblastic leukemia (T-ALL) involves the LMO2 locus, resulting in ectopic expression of the LMO2 gene in human thymocytes. The LMO2 gene was also activated in patients with X-linked Severe Combined Immune Deficiency treated with gene therapy because of retroviral insertion in the LMO2 locus. The LMO2 insertions predisposed these children to T-ALL, yet how...

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Source

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Identifiers

PMID: 21057528
DOI: 10.1038/onc.2010.495
PMCID: PMC3691994

Genes

LMO2
TAL1
GATA1
LDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.PMID 21057528Read ↗

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LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct PathwaysSemantic proximity Read ↗

TheLMO2T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell DevelopmentSemantic proximity Read ↗

LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Semantic proximity Read ↗

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.Semantic proximity Read ↗

Targeting LMO2 with a Peptide Aptamer Establishes a Necessary Function in Overt T-Cell NeoplasiaSemantic proximity Read ↗

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Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.Semantic proximity Read ↗

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