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Article

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

8 Aug 2013

Abstract excerpt

Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), including early T-cell precursor ALL (ETP-ALL) cases with poor prognosis. Lmo2 must be recruited to DNA by binding to the hematopoietic basic helix-loop-helix factors Scl/Tal1 or Lyl1. However, it is unknown which of these factors can mediate the leukemic activity of Lmo2. To address this, we...

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PMID: 23926305
DOI: 10.1182/blood-2012-09-458570

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